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Ethyl bromoacetate

Product Name:
Ethyl bromoacetate
CAS No.
105-36-2
Chemical Name:
Ethyl bromoacetate
CBNumber:
CB6852654
Molecular Formula:
C4H7BrO2
Formula Weight:
167
MOL File:
105-36-2.mol
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Ethyl bromoacetate Property

Melting point:
-38 °C
Boiling point:
159 °C(lit.)
Density 
1.506 g/mL at 25 °C(lit.)
vapor density 
5.8 (vs air)
vapor pressure 
2.6 mm Hg ( 25 °C)
refractive index 
n20/D 1.451(lit.)
Flash point:
118 °F
storage temp. 
Store below +30°C.
solubility 
water: insoluble
form 
Liquid
color 
Clear
Specific Gravity
1.506
Odor
Pungent odour
Water Solubility 
Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.
BRN 
506456
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids.
InChIKey
PQJJJMRNHATNKG-UHFFFAOYSA-N
CAS DataBase Reference
105-36-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, bromo-, ethyl ester(105-36-2)
EPA Substance Registry System
Acetic acid, 2-bromo-, ethyl ester (105-36-2)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
26-45-7/9-1/2
RIDADR 
UN 1603 6.1/PG 2
WGK Germany 
1
RTECS 
AF6000000
19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159080
Hazardous Substances Data
105-36-2(Hazardous Substances Data)
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N-Bromosuccinimide Price More Price(12)

Sigma-Aldrich Gold
Product number:
133973
Product name :
Ethyl bromoacetate
Purity:
reagent grade, 98%
Packaging:
5g
Price:
$33.1
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
133973
Product name :
Ethyl bromoacetate
Purity:
reagent grade, 98%
Packaging:
100g
Price:
$34.3
Updated:
2019/12/02
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Buy
Alfa Aesar Gold
Product number:
A10448
Product name :
Ethyl bromoacetate, 98%
Packaging:
500g
Price:
$93.6
Updated:
2020/06/24
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Buy
Alfa Aesar Gold
Product number:
A10448
Product name :
Ethyl bromoacetate, 98%
Packaging:
100g
Price:
$32.4
Updated:
2020/06/24
Buy:
Buy
Sigma-Aldrich Gold
Product number:
17020
Product name :
Ethyl bromoacetate
Purity:
purum, ≥97.0% (GC)
Packaging:
0
Price:
$0
Updated:
2019/12/02
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Buy
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Ethyl bromoacetate Chemical Properties,Usage,Production

Chemical Properties

Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is insoluble in water, but is soluble in acetone and benzene (Lide, 1999; Lewis, 1997). Ethyl bromoacetate is miscible with ethanol, ethyl ether, and with other oxygenated and aromatic solvents (Ashford, 1994; Lide, 1999). It is partially decomposed by water (Lewis, 1997).

Uses

Ethyl Bromoacetate, is used in the synthesis of metabolites of carcinogenic PAHs. Used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.

General Description

A clear, colorless liquid (b.p. 318°F). Flash point 47°C. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Toxic by ingestion, inhalation, and skin absorption; strong irritant.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

A poison. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid when exposed to heat, flame, and oxidizers. Will react with water or steam to produce toxic and corrosive fumes. To fight fire, use water as a fire blanket. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of Br-. See also BROMIDES.

Potential Exposure

Used for making pharmaceuticals; as a warning gas in poisonous, odorless gasses; as a tear gas

Shipping

UN1603 Ethyl bromoacetate, Hazard class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.

Incompatibilities

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.

Ethyl bromoacetate Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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