盐酸双芬麦兰
盐酸双芬麦兰 用途与合成方法
|
MAO-A 4.2 μM (Ki) |
MAO-B 46 μM (Ki) |
Bifemelane inhibits MAO-A in a dose-dependent manner, with K
i
s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K
i
s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.
| Animal Model: | Wistar male rats (230-270 g) are induced hypothermia by Reserpine |
| Dosage: | 20, 40, 80 mg/kg |
| Administration: | A single i.p. |
| Result: | Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃. |
盐酸双芬麦兰 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-B1558A | 1 mg | 285 | ||
| 2024-04-30 | HY-B1558A | Bifemelane HCl | 62232-46-6 | 5mg | 750 |
