丹酚酸B镁盐
丹酚酸B镁盐 用途与合成方法
Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis.
Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner.
Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons.
Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats.
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models.
| Animal Model: | Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats |
| Dosage: | 2, 8 mg/kg |
| Administration: | P.o. once daily for 16 days |
| Result: |
Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase.
Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21. |
