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What is itraconazole used to treat?

Mar 16，2024

Itraconazole is a lipophilic substance which is practically insoluble in water and dilute acidic solutions. Partition coefficient in n-octanol/aqueous buffer of pH 8.1: 5.66. The triazole antimycotic itraconazole was first synthesized at Janssen Pharmaceuticals.

Trade Names

Itrizole (Cilag), Sempera (Janssen), Siros (Cilag), Sporanox (Edward Keller, Janssen), Triasporin (Lifepharma).

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Indications

Therapy of dermatophytoses and onychomycoses with a dosing regimen of 100 to 200 mg per day. Vaginal candidosis with 200 mg/d for 3 days. Therapy of systemic infections such as candidosis and aspergillosis including disseminated infections, blastomycosis, coccidioidomycosis, histoplasmosis, and cryptococcosis with a dosing regimen of 100 to 400 (or up to 600) mg/d. Especially in aspergillosis, an early onset of therapy is important for the clinical outcome.

Side Effects

Itraconazole is generally well tolerated. CNS. Vertigo and headache: 10 %. GIT. Stomachache, vomiting, and diarrhoea were observed. Liver. Rise in transaminases and other reversible liver affections: 7 %. Metabolism. Hypokaliemia and rise in serum triglycerides.

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