1,1'-Bis(di-tert-butylphosphino)ferrocene

1. Ligand for synthesis of polycyclic indoles via Pd-catalyzed intramolecular heteroannulation.
2. Ligand for the palladium-catalyzed intramolecular arylation of aryl bromides under mild conditions.
3. Ligand for cross-coupling reactions between bromoarenes and potassium allyltrifluoroborates promoted by a catalyst prepared from Pd(OAc)2 and DTBPF selectively providing γ-coupling products.
4. Ligand for the copper-catalyzed system for the ß-boration of of a variety of α,ß-unsaturated amides.
5. Ligand for the synthesis of Paucifloral F and related indanone analogues via palladium-catalyzed α-arylation.
6. Ligand for the Pd-carbon monoxide complex catalyzed hydroxycarbonylation of aryl halides.
7. Ligand for the palladium-catalyzed β-C-glycosylation by decarboxylative allylation to normal pyran systems,and cis-2,6-disubstituted tetrahydropyrans.
8. Pd-catalyzed dearomative indole bisfunctionalization via a diastereoselective arylcyanation.
9. Ligand for the copper- DTBPF catalyzed C–H activation and carboxylation of terminal alkynes.

1,1'-BIS(DI-TERT-BUTYLPHOSPHINO)FERROCENE is an organophosphine compound and can be used as an organometallic ligand.

The rate of palladium-catalyzed amination of unactivated aryl chlorides is accelerated by sterically hindered chelating alkyl phosphines, ie, 1,1'-bis(di-tert-butylphosphino)ferrocene.