环孢菌素 H
环孢菌素 H 性质
| 熔点 | 148-151°C |
|---|---|
| 沸点 | 1293.8±65.0 °C(Predicted) |
| 密度 | 1.016±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶、加热、超声处理） |
| 酸度系数(pKa) | 13.32±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D -100 to -115°, c = 0.5 in methanol |
环孢菌素 H 用途与合成方法
The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a K i of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a K i of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca 2+ concentration ([Ca 2+ ]i), O2- formation, and beta-glucuronidase release with K i values of 0.08, 0.24, and 0.45 μM, respectively.
Cyclosporin H (5 mg/kg; i.p.; before LPS or HCl challenge) attenuats lung injury induced by LPS or HCl (a lung injurymodel).
环孢菌素 H 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-P1122 | 1 mg | 1236 | ||
| 2024-01-25 | HY-P1122 | 环孢菌素 H | 83602-39-5 | 5mg | 3400 |
